Issues

• Summary of Dundee DMPK Data for OSM Compounds

  Biological DataData Check/Proof Read
  OpenSourceMalaria/Series3#40 · Filter by author yinuowang0812 opened on Aug 19, 2025

• XRS Project Summary — Progress and Upcoming Plans

  Biological DataCollaboration RequestFYIinput neededWriting
  OpenSourceMalaria/Series3#39 · Filter by author yinuowang0812 opened on May 7, 2025
  1

  

• New analogues sent for biological testing JAN 2025

  Biological Data
  OpenSourceMalaria/Series3#38 · Filter by author yinuowang0812 opened on Jan 13, 2025

• XRS Box (106-aa adducts) biological testing results (updating)

  Biological DataNeeds UpdatingWriteup required
  Task

  OpenSourceMalaria/Series3#37 · Filter by author yinuowang0812 opened on Jun 17, 2024
  2

  

• Synthetic Challenges in Miyaura Borylation of Bromo-Thienopyrimidine

  Being Synthesised Nowinput neededquestion
  OpenSourceMalaria/Series3#36 · Filter by author yinuowang0812 opened on Mar 4, 2024
  11

  

• New analogues sent for biological testing JAN 2024

  Biological Data
  OpenSourceMalaria/Series3#35 · Filter by author yinuowang0812 opened on Feb 26, 2024
  2

• Pyridone sulfonamide analogues sent for biological testing MAY 2023

  Biological Data
  OpenSourceMalaria/Series3#33 · Filter by author yinuowang0812 opened on May 15, 2023

• Sulfamate analogues sent for biological testing Feb 2023

  Biological Data
  OpenSourceMalaria/Series3#32 · Filter by author edwintse opened on Mar 6, 2023
  1

• Novel OSM106-sulfamate analog - progress and challenges

  Being Synthesised Nowinput neededquestionSearch/Data Needed
  OpenSourceMalaria/Series3#31 · Filter by author yinuowang0812 opened on Oct 12, 2022
  3

  

• A Check on the Completeness of OSM Series 3 Compounds in Master List

  Data Check/Proof ReadWriting
  OpenSourceMalaria/Series3#30 · Filter by author mattodd opened on Feb 13, 2022
  2

  

• Parasite Reduction Ratio Data Received

  Biological DataFYI
  OpenSourceMalaria/Series3#29 · Filter by author mattodd opened on Jan 28, 2022
  

• Dose Predictions Using MMVSola

  ADMEquestionSearch/Data Needed
  OpenSourceMalaria/Series3#28 · Filter by author mattodd opened on Oct 20, 2021
  

• IC50 and Hill Slope data from STPH Hypoxanthine assay

  Biological DataFYI
  OpenSourceMalaria/Series3#27 · Filter by author mattodd opened on Oct 19, 2021
  

• New in vivo mouse PK data

  ADMEBiological Data
  OpenSourceMalaria/Series3#26 · Filter by author mattodd opened on Aug 4, 2021
  

• Docking Experiments and Comparison of CA Homology Model with Known hCAII Crystal Structure

  Mechanism of Action
  OpenSourceMalaria/Series3#25 · Filter by author Skame161 opened on Feb 27, 2021
  5

• Structure of human CAII with OSM-S-106

  Biological DataMechanism of Action
  OpenSourceMalaria/Series3#24 · Filter by author Sarahlischen opened on Feb 23, 2021
  14

• What is target validation?

  OpenSourceMalaria/Series3#22 · Filter by author mbhebhe opened on Jul 2, 2020
  4

• Homology model of PfηCarbonic Anhydrase

  OpenSourceMalaria/Series3#21 · Filter by author drc007 opened on Mar 30, 2020
  3

• UNC Kinome Scan

  OpenSourceMalaria/Series3#17 · Filter by author mbhebhe opened on Jul 22, 2019
  9

• Carbonic Anhydrase - Relevance to Mechanism of Action

  Mechanism of Action
  OpenSourceMalaria/Series3#14 · Filter by author mattodd opened on Feb 7, 2019
  20

  

• Commercially available compounds similar to OSM-S-106 (Late Jan 2019 search)

  Molecule SuggestionNeeds Action
  OpenSourceMalaria/Series3#13 · Filter by author mbhebhe opened on Jan 29, 2019
  14

• More analogues of OSM-S-137 ?

  Molecule Suggestion
  OpenSourceMalaria/Series3#9 · Filter by author MFernflower opened on Oct 16, 2018
  3